Список исследуемых препаратов для лечения болезни Паркинсона
Список исследуемых препаратов для лечения болезни Паркинсона
Это список исследуемых препаратов для лечения болезни Паркинсона, то есть лекарств, которые в настоящее время разрабатываются для клинического применения при лечении болезни Паркинсона, но еще не одобрены. Их также могут называть исследуемыми противопаркинсоническими средствами.
Химические/генерические названия указаны первыми, за ними следуют кодовые названия на стадии разработки, синонимы и торговые названия в скобках. Формат пунктов списка: «Название (синонимы) – механизм действия [ссылка]».
Этот список был последний раз всесторонне обновлен в сентябре 2025 года. Со временем он, вероятно, устареет.
На стадии разработки[править | править код]
Предрегистрация[править | править код]
- AIP-201 – усилитель позитронно-эмиссионной томографии (ПЭТ) – диагностика
- Леводопа/карбидопа подкожно (ND-0612; ND-0680) – комбинация леводопы (предшественник дофамина) и карбидопы (ингибитор ароматической L-аминокислотной декарбоксилазы (AAAD))
Фаза 3[править | править код]
- Альтропан (123-I Altropane; [123I]-E-IACFT; NAV-5001; O-587) – ингибитор обратного захвата дофамина (DRI) и усилитель однофотонной эмиссионной компьютерной томографии (ОФЭКТ)
- Апоморфин (Aporon) – неселективный агонист дофаминовых рецепторов и другие действия
- Апоморфин сублингвальная пленка (APL-130277; Kynmobi) – неселективный агонист дофаминовых рецепторов и другие действия
- Бемданепроцел (BRT-DA01; DA-01; MSK-DA01; плюрипотентные стволовые клетки, производные дофаминергических нейронов) – замещение дофаминергических клеток
- Бунтанетан ((+)-(3aR)-фенсерин; (+)-фенсерин; ANVS-401; ANVS-405; ANVS402; позифен) – различные действия
- 18F-LBT-999 ([18F]-LBT-999; LBT-999) – ингибитор обратного захвата дофамина (DRI) и усилитель позитронно-эмиссионной томографии (ПЭТ) – диагностика
- Набилон контролируемого высвобождения (Nabilone FDT) – агонист каннабиноидных рецепторов CB₁ и CB₂
- Прамипексол/разагилин (P2B-001; разагилин/прамипексол) – комбинация прамипексола (агонист дофаминовых рецепторов D₂-подобного типа) и разагилина (ингибитор МАО-B)
- Ремлифансерин (ACP-204) – антагонист серотониновых рецепторов 5-HT₂A – психоз при болезни Паркинсона
- Соленгепра (CVN-424) – ингибитор G-белок-сопряженного рецептора 6 (GPR6)
- Тавападон (CVL-751; PF-6649751; PF-06649751) – агонист дофаминовых рецепторов D₁ и D₅
Фаза 2/3[править | править код]
- BHV-8000 (TLL-041) – ингибитор янус-киназы 1 и ингибитор киназы TYK2
- Мездопетам (IRL-790) – антагонист дофаминовых рецепторов D₂ и D₃ и другие действия
Фаза 2[править | править код]
- 18F PI-2620 ([18F]PI-2620; PI-2620) – усилитель позитронно-эмиссионной томографии (ПЭТ) – диагностика
- AB-1005 (AAV2-GDNF; AMT-140; терапия аденосвязанным вирусом-GDNF) – перенос генов и стимулятор экспрессии нейротрофического фактора глиальных клеток (GDNF)
- Аффитоп PD01 (ACI-7104; ACI-7104.056; Affitope-PD01A; PD-01; PD-01A) – пептидная вакцина против α-синуклеина
- Альтропан 123I (радиофармацевтическое средство для визуализации транспортера дофамина (DAT)) – ингибитор обратного захвата дофамина (DRI) и усилитель однофотонной эмиссионной компьютерной томографии (ОФЭКТ) – диагностика
- Апоморфин ингаляционный (AZ-009; Staccato® Apomorphine) – неселективный агонист дофаминовых рецепторов и другие действия
- Апоморфин интраназальный (AL-101) – неселективный агонист дофаминовых рецепторов и другие действия
- Апрепитант/прамипексол (ALTO-208; CTC-413) – комбинация апрепитанта (антагонист нейрокининовых рецепторов NK₁) и прамипексола (агонист дофаминовых рецепторов D₂-подобного типа)
- Без
Ссылки[править | править код]
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